Explore the Science Behind AVNT™

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Mechanism of Action in Summary
01

Downregulate Inflammation

Delivers targeted stimulation to neuro-inflammatory pathways, addressing the root cause of 70% of health conditions.

02

Modulate Autonomic Health

Rebalances the autonomic nervous system  by promoting the parasympathetic, improving heart rate variability and reducing the effect of stress

03

Facilitate Neuroplasticity

Continuous pulses of targeted bioelectric simulation strengthen neural pathways, improving cognition and resilience to stress.

70% of common health conditions can be addressed with precision auricular vagal neuromodulation therapy

Health Benefits

Science Behind Auricular Vagal Neuromodulation Therapy AVNT™

Changes in inflammatory biomarkers during 3 months of AVNT(™) resulted in significant (p<0.05) reductions in TNF-ɑ and IL-8 which was associated with clinical improvement in heart failure.
Reference:
Stavrakis, S., Elkholey, K., Morris, L., Niewiadomska, M., Asad, Z.U.A. and Humphrey, M.B. (2022). Neuromodulation of Inflammation to Treat Heart Failure With Preserved Ejection Fraction: A Pilot Randomized Clinical Trial. Journal of the American Heart Association, 11(3).
Autonomic health is correlated with an improvement in heart rate variability which improved and was maintained after just 5 minutes of AVNT(™).
Reference:
Geng, D., Yang, K., Fu, Z., Zhang, Y., Wang, C. and An, H. (2022). Circadian stage-dependent and stimulation duration effects of transcutaneous auricular vagus nerve stimulation on heart rate variability. PLOS ONE, 17(11), p.e0277090.
2 weeks of AVNT(™) resulted in significant improvements in recall and short term memory.
Reference:
Jandackova, V., Vasendova, V., Jackowska, M. and Koenig, J. (2023). The effect of long-term non-invasive vagus nerve stimulation on cognitive performance: results from a randomized placebo controlled trial. Brain stimulation, [online] 16(2), pp.6–6.

AVNT™ in Research

Scientific Publication
Atrial Fibrillation

Randomized controlled trial observes reduced AF Burden by 85% with AVNT™

Atrial Fibrillation is the most common form of cardiac arrhythmia and is a significant risk factor for life threatening cardiac events such as ischaemic stroke, heart failure and mortality.

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Scientific Publication
POTS

AVNT™ improves physiological markers used in the diagnosis of Postural Orthostatic Tachycardia Syndrome

Postural Orthostatic Tachycardia Syndrome (POTS) POTS is poorly understood and disproportionately affects young women. It’s characterised by tachycardia, lightheadedness, and fainting upon standing.

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Scientific Publication
Post Viral Syndromes

Multiple studies observe significant improvements in function, mental health and symptoms in patients with Long Covid

Long Covid is a debilitating condition that is poorly understood but can affect up to 35% of patients post Covid infection. Symptoms can be similar to other post viral syndromes such as ME/ Chronic Fatigue Syndrome

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Scientific Publication
Cognitive Improvement

Randomized controlled trial shows significantly improved short term memory and recall with 2 weeks of AVNT™

Memory loss can be the first symptom of cognitive impairment and dementia. Dementia has been associated with autonomic dysfunction and studies have linked higher heart rate variability with improved cognitive function.

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FeaturedScientific Publications

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Scientific Publication

Multiple studies observe significant improvements in function, mental health and symptoms in patients with Long Covid

Scientific Publication

Randomized controlled trial observes reduced AF Burden by 85% with AVNT™

Scientific Publication

AVNT™ improves physiological markers used in the diagnosis of Postural Orthostatic Tachycardia Syndrome

Scientific Publication

Randomized controlled trial shows significantly improved short term memory and recall with 2 weeks of AVNT™

Scientific Publication

TREAT AF (Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation): A Randomized Clinical Trial

Scientific Publication

Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial

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